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Open platform · The University of Texas at Austin

Brain data across scales. One place to analyze, share and publish it.

Electron and light microscopy, PS-OCT, MRI, fMRI, EEG and MEG. Run reproducible analyses on shared supercomputers, look at the results in your browser, publish them with a DOI.

Start a projectBrowse Apps and Datasets
400+Apps
5,000+users
300+public datasets
64publications with DOIs
nm → cmscales

Free for researchers · funded by NIH, NSF, DoD, Kavli, Wellcome

Measurements across scales

Every representation of the brain, from synapses to systems.

Stylised views of the datatypes that are live on the platform today, in the order of the scale they measure. Upload your own or import from public archives; 139 datatypes keep Apps interoperable.

Browse public datasets →
Electron microscopy
nm · Neuroglancer
Lightsheet microscopy
µm · OME-Zarr
PS-OCT · tract tracing
µm–mm · Zarr
White-matter tracts
dMRI · TRX
Brain surfaces
GIfTI · parcellations
Connectivity matrices
connectome · CSV
Functional maps
fMRI · BIDS
MEG · EEG
FIF · NWB
nm · synapsesµm · cellsmm · circuitscm · systemswhole brain
Import fromOpenNeuroBossDBDANDIezBIDS (DICOM → BIDS)Your computer
FormatsBIDSNIfTIOME-Zarr 0.5Neuroglancer precomputedTRXNWBFIF
From the publications

Science published on brainlife, with the people who made it.

Every card is a record from the publication registry: title, DOI, authors and institutions, and the clips and banner images the authors attached. The order shuffles on each visit.

All 64 publications →
Video · 8 clips
Heterogeneity of white-matter organization in the human brainWhite-matter, which contains the long-range axons connecting different brain regions, makes up nearly half the human brain, yet the three-dimensional organization of individual …Clay Reid, Wan-Qing Yu · Allen Institute for Brain Science · Allen Institute
20269 Neuroglancer views10.25663/brainlife.pub.69
Retinotopic Connectivity TemplateA population-derived representation of visual white-matter connectivity constructed from diffusion tractography data in over 1,000 subjects from the Human Connectome Project. It…Gabriele Amorosino, Brad Caron, Junbeom Kwon, Marisa Carrasco, Clay Reid, Christophe Lenglet, Jan Zimmermann and 4 more · Pestilli Lab, The University of Texas at Austin · University of Texas at Austin
202610.25663/brainlife.pub.67
EEGManyPipelinesThis project contains the data that was used in the EEGManyPipelines-projectElena Cesnaite, andrea vitale, Annalisa Pascarella, Mikkel C. Vinding, Johannes Algermissen, Nastassja L. Fischer, Claudia Gianelli and 4 more · Münster University · university of trento
2026EEGbehavioral data10.25663/brainlife.pub.66
Video · 12 clips
Center for Mesoscale ConnectomicsBrain function is built atop connections made between neurons. The proposed Center for Mesoscale Connectomics will use multiple imaging and neuroanatomical methods across nonhum…Taylor Grafft · Brainlife
2026Neuroscience10 Neuroglancer views10.25663/brainlife.pub.64
No media yet
Longitudinal study of structural brain neuroplasticity and cognitive reserve: a case reportThis publication contains processed morphometric brain data (parc-stats) demonstrating longitudinal cortical thickness and subcortical volume changes between 2023 and 2026. The …Marina Ermoshina · Independent Researcher
2026neuroplasticity,freesurfer,10.25663/brainlife.pub.73
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Preprocessing SRPBS Multi-disorder MRI Dataset (unrestricted)Preprocessing with freesurfer and fmriprepJoy Lee-Shi · n/a
202610.25663/brainlife.pub.72
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White Matter Tract Segmentation Benchmark Dataset: Cambridge Centre for Ageing and Neuroscience (CamCAN)This dataset contains preprocessed diffusion MRI data and white matter tract segmentation outputs derived from the Cambridge Centre for Ageing and Neuroscience (CamCAN) cohort, …Junbeom Kwon, Gabriele Amorosino, Franco Pestilli · University of Texas at Austin · Pestilli Lab, The University of Texas at Austin
202610.25663/brainlife.pub.70
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White Matter Tract Segmentation Benchmark Dataset: Human Connectome Project Young Adult (HCP-YA)This dataset contains preprocessed diffusion MRI data and white matter tract segmentation outputs derived from the Human Connectome Project Young Adult (HCP-YA) cohort. Fiber or…Junbeom Kwon, Gabriele Amorosino, Franco Pestilli · University of Texas at Austin · Pestilli Lab, The University of Texas at Austin
202610.25663/brainlife.pub.68
No media yet
GLIODEF DatasetA synthetic dataset for bundle segmentation in glioma patientsPaolo Avesani · Fondazione Bruno Kessler
202610.25663/brainlife.pub.65
No media yet
mri analysismri short descriptionAzam Rashid · NeuroCogni AI
202510.25663/brainlife.pub.63
No media yet
Center for Mesoscale ConnectomicsBrain function is built atop connections made between neurons. The proposed Center for Mesoscale Connectomics will use multiple imaging and neuroanatomical methods across nonhum…Shaun Warrington, Mohamed Kotb Selim, Benjamin C. Tendler, Steen Moeller, Hamza Farooq, Wenchuan Wu, Pramod Kumar Pisharady and 13 more · University of Nottingham · Centre for Integrative Neuroimaging, University of Oxford
202510.25663/brainlife.pub.62
No media yet
A labeled Clinical-MRI dataset of Nigerian brainsThis dataset contains pseudonymized structural MRI (T1w, T2w, FLAIR) data of clinical quality, with 35 images from healthy control subjects, 31 images from individuals diagnosed…Franco Pestilli, Eberechi Wogu, Patrick Filima, Dan Levitas, Brad Caron · The University of Texas at Austin · University of Port Harcourt, Choba, Rivers State, Nigeria.
2024MRIFLAIR10.25663/brainlife.pub.61
Apps

400+ Apps, run on shared supercomputers.

Any GitHub repository becomes a containerized App. Jobs run on TACC, Jetstream2 and ACCESS, and every output opens in NiiVue or Neuroglancer. Each card names what the App does and who maintains it.

Browse all Apps →
anatomy-preprocessingAlign T2 to ACPC Plane (HCP-based)

This app will align a T1w image to the ACPC plane (specifically, the MNI152_T1_1mm template from FSL using a 6 DOF alignment via FSL commands. This protocol was adapted from the HCP Preprocessing Pipe

Maintained by The Brainlife Team, Brent McPherson, Brad Caronbrainlife/app-hcp-acpc-alignment4,407,496 runs · 223 users
analysis · anatomy-preprocessingFreesurfer 7.3.2

Freesurfer segments the t1w anatomical data into functionally different parts of the brain. Segmentation/parcellation can then be fed to many other subsequent analysis.

Maintained by Giulia Berto, Brad Caron, The Brainlife Team, Franco Pestillibrainlife/app-freesurfer774,031 runs · 992 users
AppCompute summary statistics of diffusion measures from Freesurfer Parcellation (volume)

See the repository for details.

Maintained by Brad Caronbrainlife/app-freesurfer-stats179,838 runs · 285 users
AppMulti-Atlas Transfer Tool

brainlife.io version of maTT

Maintained by The Brainlife Team, Josh Faskowitz, Franco Pestilli, Brent McPherson, Brad Caronfaskowit/app-multiAtlasTT145,960 runs · 154 users
fmri · preprocessingfMRIPrep - Volume Output

fMRIPrep is a functional magnetic resonance imaging (fMRI) data preprocessing pipeline that is designed to provide an easily accessible, state-of-the-art interface that is robust to variations in scan

Maintained by Brad Caron, Daniel Levitas, David Hunt, Giulia Berto, Josh Faskowitz, The Brainlife Team, Eva Bacasbrainlife/app-fmriprep137,032 runs · 351 users
AppFSL Anat (mp2rage)

See the repository for details.

Maintained by Brad Caronbrainlife/app-fsl-anat115,250 runs · 468 users
diffusion-mri · mrimrtrix3 preprocess

Run the recommended preprocessing procedure provided by mrtrix3. The options available mostly reflect the optimal DESIGNER pipeline that was recently proposed. This App runs for >15 on topup if both P

Maintained by Brent McPherson, Giulia Berto, Brad Caronbrainlife/app-mrtrix3-preproc76,615 runs · 165 users
AppCompute summary statistics of diffusion measures mapped to visual regions binned by eccentricity - Benson14

See the repository for details.

Maintained by Brad Caronbrainlife/app-cortex-tissue-mapping-stats62,435 runs · 111 users
analysisPosterior Associative White Matter Tracts Segmentation

Classifies streamlines into known anatomical tracts.

Maintained by Brad Caron, Daniel Bullock, Franco Pestilli, Giulia Bertobrainlife/app-wmaSeg48,959 runs · 123 users
anatomy-preprocessingtest

Brain Extraction via FSL's BET command

Maintained by Sandesh PATILbrainlife/app-FSLBET47,688 runs · 182 users
postprocessingCompute average cortexmap data for group analysis

This app will map volumated measure files (i.e. tensor, NODDI) to the cortical surface following Fukutomi et al (2018; 10.1016/j.neuroimage.2018.02.017) using Connectome Workbench.

Maintained by Brad Caronbrainlife/app-cortex-tissue-mapping46,362 runs · 25 users
AppTractography quality check

Compute many statistics from your input tractogram and any (optionally input) associated classification structure. These statistics can be used to facilitate quality assurance on your tractography and

Maintained by Brad Caron, Franco Pestilli, Giulia Berto, The Brainlife Teambrainlife/app-tractographyQualityCheck42,161 runs · 73 users
Tools ecosystem

The tools around the platform, and the ones it runs.

brainlife builds a few tools of its own, partners on others, and wraps the community’s standard software as Apps so it runs on shared compute without installation.

brainlife productezBIDS

DICOM to BIDS in the browser, with NiiVue built in.

brainlife productDICOMpare

Check scanner protocols against a reference before data leaves the site.

upcomingezGov

Data-sharing governance made simple: agreements, access, provenance.

partner projectNiiVue

WebGL2 viewer for volumes, surfaces and streamlines on any device.

tool we useNeuroglancer

Google’s WebGL viewer for terabyte EM and microscopy volumes.

supported toolFreeSurfer

Cortical surfaces and parcellations from T1w.

supported toolFSL

Brain extraction, registration, diffusion and fMRI tools.

supported toolMRtrix3

Diffusion preprocessing and anatomically constrained tractography.

supported toolDIPY

Diffusion imaging in Python: denoising, models, tracking.

supported toolfMRIPrep

Robust functional MRI preprocessing.

supported toolQSIPrep

Diffusion MRI preprocessing and reconstruction.

supported toolANTs

Registration, segmentation and template building.

and 400+ more as Apps
Infrastructure

Containers, an orchestrator, and public compute.

ContainersDockerSingularity / Apptainer
OrchestrationAmaretti (brainlife’s workflow service)
ComputeTACCJetstream2 cloudEGI cloudACCESS
StorageAWS Open DataObject storage for OME-Zarr and precomputed volumes
People

Built by the people who publish on it.

Authors of the most recent publications, pulled from the publication registry so this never goes stale.

Clay ReidWan-Qing YuGabriele AmorosinoBrad CaronJunbeom KwonMarisa CarrascoChristophe LengletJan ZimmermannEssa YacoubKamil UgurbilSarah HeilbronnerFranco PestilliElena Cesnaiteandrea vitaleAnnalisa PascarellaMikkel C. VindingJohannes AlgermissenNastassja L. FischerClaudia GianelliDarinka TrübutschekYu-Fang YangGustav NilsonneNiko BuschTaylor Grafft
brainlife.io · Pestilli Lab, The University of Texas at AustinCode MIT · content CC BY 4.0 · GitHub · Contact